Clotrimazole CAS 23593-75-1 is a specific inhibitor of Ca2+-activated K+ channels. It is an antifungal azole. Clotrimazole is a derivative of imidazole and has similar antimicrobial action and activity to ketoconazole. It inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.
Clotrimazole has been used:
(1)to study the upregulation of the gene ERG11 that codes for an azole target enzyme lanosterol demethylase, in Candida species, upon treatment with azole antibiotics.
(2)to study the development of resistance in Candida species isolated from patients undergoing prolonged antifungal treatment
to induce stress granules via mitochondrial stress.
(3)for the inhibition of in vitro formation of high density sickle cells induced by treatment with 1-chloro-2,4-dinitrobenzene (CDNB)
to inhibit cytochrome P450 enzyme in cell cultures.
The clotrimazole supplied by Shanghai Jiaoze meets the HPLC99% standard.
